聶文鋒，男，安徽安慶人，博士，教授，泰山學(xué)者青年專(zhuān)家，研究方向?yàn)橹参锉碛^(guān)遺傳學(xué)與設(shè)施番茄生長(zhǎng)發(fā)育調(diào)控。
2024-至今 山東農(nóng)業(yè)大學(xué)，園藝科學(xué)與工程學(xué)院，教授
2020-2024揚(yáng)州大學(xué)園藝系，校拔尖人才，校聘教授
2017-2020中國(guó)科學(xué)院上海逆境生物學(xué)研究中心，助理研究員
2015-2017中國(guó)科學(xué)院上海生命科學(xué)研究院，博士后
2012-2014美國(guó)普渡大學(xué)，園藝與景觀(guān)設(shè)計(jì)系，聯(lián)合培養(yǎng)博士研究生
2009-2014浙江大學(xué)，農(nóng)業(yè)與生物技術(shù)學(xué)院，蔬菜學(xué)博士
2005-2009吉林大學(xué)，植物科學(xué)學(xué)院，園藝學(xué)士
主要研究?jī)?nèi)容：
DNA序列上的甲基化修飾（5mC）和組蛋白H2A.Z變體是兩種重要且保守的表觀(guān)遺傳修飾，二者在植物全基因組整體層面相互拮抗而在局部特異性DNA序列上相互協(xié)同，進(jìn)而對(duì)植物細(xì)胞的基因表達(dá)調(diào)控產(chǎn)生重要影響。5mC和H2A.Z等表觀(guān)遺傳修飾可充分釋放植物表型可塑性的潛力，在調(diào)控番茄等蔬菜作物的生長(zhǎng)發(fā)育、抗逆性和品質(zhì)形成等過(guò)程中發(fā)揮重要作用。
DNA主動(dòng)去甲基化是維持細(xì)胞5mC含量和分布的重要生物學(xué)過(guò)程，決定基因是否表達(dá)和表達(dá)水平。本人主要圍繞番茄的經(jīng)濟(jì)性狀（產(chǎn)量、品質(zhì)和活性成分）形成過(guò)程中的環(huán)境塑造機(jī)制及其表觀(guān)遺傳調(diào)控，深入研究DNA去甲基化和組蛋白結(jié)構(gòu)變化（如H2A.Z變體、乙酰化修飾等）在番茄植株對(duì)鹽堿、低溫、弱光等逆境脅迫的應(yīng)答中以及在果實(shí)發(fā)育和功能活性物質(zhì)積累中的機(jī)制、功能和應(yīng)用，為優(yōu)化設(shè)施蔬菜栽培提供新理論和新方法。
所在設(shè)施蔬菜抗性與品質(zhì)調(diào)控團(tuán)隊(duì)每年招收蔬菜生理與分子生物學(xué)方向的碩、博研究生，博士后，歡迎老師、同學(xué)來(lái)實(shí)驗(yàn)室交流！
主要科研項(xiàng)目：
（1）國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，弱光環(huán)境下組蛋白H2A.Z變體調(diào)控番茄株型的表觀(guān)遺傳機(jī)制，2025/01-2028/12，主持；
（2）山東省級(jí)人才工程，泰山學(xué)者青年專(zhuān)家項(xiàng)目，基于DNA去甲基化的番茄表觀(guān)遺傳種質(zhì)構(gòu)建及應(yīng)用研究，2025/01-2027/12，主持；
（3）山東農(nóng)業(yè)大學(xué)，人才引進(jìn)科研啟動(dòng)經(jīng)費(fèi)（“沖一流”建設(shè)專(zhuān)項(xiàng)經(jīng)費(fèi)），2024/09-2029/08主持；
（4）國(guó)家自然科學(xué)基金委員會(huì)，青年科學(xué)基金項(xiàng)目，32002046，DNA去甲基化酶CsDML4調(diào)控水蘇糖合成酶基因CsSTS表達(dá)和黃瓜果實(shí)膨大的機(jī)理，2021/01-2023/12主持；
（5）江蘇省科學(xué)技術(shù)廳，江蘇省自然科學(xué)青年基金項(xiàng)目，組蛋白變體H2A.Z調(diào)控番茄植株對(duì)亞低溫響應(yīng)的機(jī)理，2020/07-2023/06，主持;
（6）國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，番茄根結(jié)線(xiàn)蟲(chóng)抗性反應(yīng)中redox介導(dǎo)的溫敏性及其調(diào)控機(jī)制，2013/01-2016/12，參與。
主要學(xué)術(shù)論文（#為共同第一作者，*為通訊作者）：
(1) Nie, W.F.*, Mao, Y.Y., Xin E. and Liu, R.* Actin-related protein ARP4 and ARP6 antagonistically regulate DNA demethylase ROS1 in plants. Plant Physiology, 2024, 195(1):279-282.
(2) Nie, W.F#, Li, Y.#, Chen, Y., Guang, Y., Zhou, Y.,* and Yang, Y.*Spectrum-dependent environmental regulation guides the morphogenesis, architecture, and flowering of pepper plants. Journal of Photochemistry and Photobiology B-Biology, 2023, 241:112673.
(3) Zhou, X.#, Wei, M.#, Nie, W.F.#, Xi, Y., Li, P., Zheng, Tang, Q.,K., Satheesh, V., Wang, Y., Luo, J., Du, X., Liu, R., Yang, Z., La, H., Zhong, Y., Yang, Y., Zhu, J.K., Du, J.* and Lei, M.* The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. Journal of Integrative Plant Biology, 2022, 64(12):2385-2395.
(4) Xu, A., Wei, N., Zhou, S., Hu, H., Bie, Z., Nie, W.F.*, Cheng, F.*. Thioredoxin h2 inhibits MAPK3 phosphorylation to regulate the CBF2 COR signaling pathway in response to chilling stress in Citrullus lanatus. Horticulture Research, 2022, 10(2):uhac256.
(5) Yang, X, Zhang, X, Yang, Y, Zhang, H, Zhu, W.* and Nie, W.F.*Histone variant Sl_H2A.Z regulates the carotenoids biosynthesis and gene expression during the tomato fruit ripening. Horticulture Research, 2021, 8, 58.
(6) Liu, P. #, Nie W.F. # *, Xiong, X., Wang, Y., Jiang, Y., Huang, P., Lin, X., Qin, G., Huang, H., Niu, Q., Du, J., Lang, Z., Lozano-Duran R. and Zhu, J.K.(*)A novel protein complex that regulates active DNA demethylation in Arabidopsis. Journal of Integrative Plant Biology,2021, doi:10.1111/jipb.13045.
(7) Jiang, Y.#, Ding, X.#, Wang, J., Zou, J. and Nie, W.F.*Decreased low-light regulates plant morphogenesis through the manipulation of hormone biosynthesis in Solanum lycopersicum. Environmental and Experimental Botany,2021, 185.
(8) Nie, W.F.*DNA methylation: from model plants to vegetable crops. Biochemical Society Transactions, 2021, BST20210353. doi: https://doi.org/10.1042/BST20210353
(9) Wang, J.#, Feng, Y.#, Ding, X.#, Huo, J., Nie, W.F.* Identification of long non-coding RNAs associated with tomato fruit expansion and ripening by strand-specific paired-end RNA Sequencing. Horticulturae, 2021, 7, 522.
(10) Yang, X.#, Liu, Y.#, Zhang, H.#, Wang, J., Zinta, G., Xie, S., Zhu W.* and Nie, W.F.* Genome-wide identification of circular RNAs in response to low-temperature stress in tomato leaves. Frontiers in Genetics, 2020, 11.
(11) Nie, W.F.#, Lei, M. #, Zhang, M., Tang, K., Huang, H., Zhang, C., Miki, D., Liu, P., Yang, Y., Wang, X., Zhang, H., Lang, Z., Liu, N., Xu, X., Yelagandula, R., Zhang, H., Wang, Z., Chai, X., Andreucci, A., Yu, J.Q., Berger, F., Lozano-Duran, R. and Zhu, J.K.*. Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation in Arabidopsis. Proc Natl Acad Sci USA, 2019, 116 (33): 16641-16650.
(12) Nie W.F.*, Wang M.M., Xia X.J., Zhou Y.H., Shi K., Chen Z.X. and Yu J.Q. (*). Silencing of tomato RBOH1 and MPK2 abolishes brassinosteroid-induced H2O2 generation and stress tolerance, Plant Cell and Environment, 2013, 36: 789-803.
(13) 聶文鋒*; 王金玉; 高春娟; 陳學(xué)好*; 表觀(guān)遺傳修飾調(diào)控園藝植物果實(shí)發(fā)育的研究進(jìn)展, 園藝學(xué)報(bào), 2022, 49 (3): 671-686.
(14) Lei, M.#, La, H.G.#, Lu, K., Wang, P., Miki, D., Ren, Z., Duan, C.G., Wang, X., Tang, K., Zeng, L., Yang, L., Zhang, H., Nie, W.F., Liu, P., Zhou, J., Liu, R., Zhong, Y., Liu, D. and Zhu, J.K.* Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci USA, 2014, 111, 527-532
(15) Lang, Z.#, Lei, M.#, Wang, X., Tang, K., Miki, D., Zhang, H., Mangrauthia, S., Liu, W., Nie, W.F., Ma, G., Yan, J., Duan, C.G., Hsu, C.C., Wang, C., Tao, W., Gong, Z. and Zhu, J.K.* The methyl-CpG-binding protein MBD7 prevents DNA hypermethylation and transcriptional gene silencing by facilitating active DNA demethylation. Molecular Cell, 2015, 57, 971-983.
(16) Yang, Y., La, H., Tang, K., Miki, D., Yang, L., Wang, B., Duan, C.G., Nie, W.F., Wang, X., Wang, S., Pan, Y., Tran, E.J., An, L., Zhang, H.* and Zhu, J.K.* SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis. Nucleic Acids Research, 2017, 45, 181-197.
(17) Yang, Y.#, Tang, K.#, Datsenka, T.U.#, Liu, W., Lv, S., Lang, Z., Wang, X., Gao, J., Wang, W., Nie, W.F., Chu, Z., Zhang, H., Handa, A. K., Zhu, J. K. and Zhang, H. Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome. Journal of Integrative Plant Biology, 2019, 61(12): 1224-1242
(18) Zhao, C.Z.#*, Jiang, W.#, Zayed, O.#, Liu, X., Tang, K., Nie, W.F., Li, Y.L., Xie, S.J., Li, Y., Long, T.D., Liu, L. L., Zhu, Y.F., Zhao, Y. and Zhu, J.K.* The LRXs-RALFs-FER module controls plant growth and salt stress responses by modulating multiple plant hormones. National Science Review, 2021, 8
(19) Huang, P.#, Huang, H.#, Lin, X.Q., Liu, P., Zhao, L., Nie, W.F., Zhu, J.K., and Lang, Z.B. MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation. Plant Journal, 2021, 108, 347-357.
(20) Wang, Z.#, Wang M.#, Yang, C., Zhao, L., Qin, G., Peng, L., Zheng, Q., Nie, W.F., Song, C.P., Shi, H., Zhu, J.K.* and Zhao, C.*. SWO1 modulates cell wall integrity under salt stress by interacting with importin ɑ in Arabidopsis. Stress Biology, 2021, 1:9
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